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  Morphogenesis, Signaling, Modeling
  Dynamics and Expression of plant Genomes
  Adaptation of Plants to the Environment
  Reproduction and Seeds
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The department “Dynamics and Expression of the Genome” employs genetics, cytology, molecular biology and protein biochemistry to investigate the essential mechanisms controlling the structure and function of the genome during meiosis (recombination) and genomic shock (polyploidism), and following biotic and abiotic stresses (control of transposable elements and variations in the epigenetic state of genes implicated in stress responses). Our department also studies the transcriptional (chromatin dynamics and the stability of epigenetic states) and posttranscriptional (processing of endogenous and exogenous aberrant RNAs by RNA Quality Control and RNA silencing pathways) mechanisms controlling gene expression. These studies are carried out in several model plants including the crucifers Arabidopsis thaliana and Brassica napus, the solanaceous species Nicotiana tabacum and Solanum esculentum and basal land plants such as the moss Physcomitrella patens.

 

Groups

- "Meiosis and Recombination" team studies the key steps of meiosis and meiotic recombination (meiotic cell cycle regulation, initiation of meiotic recombination, double strand break repair pathways, control of the crossing over/non crossover ratio, polyploidization mechanisms, control of recombination in polyploids, and the role of chromatin structure on the distribution of meiotic recombination events). A subset of our group also studies somatic homologous recombination with the aim of developing gene targeting strategies.

- "Host-Retrotransposon Interactions (RETROS)" team examines the impact of retrotransposons in Solanaceae, from the control of their activities (particularly in response to stress or allopolyploidization) to their molecular evolution, as well as their evolutionary and functional impact. The group also looks at the impact of transcriptional activation of retrotransposons on the expression of cellular genes.

- "Epigenetic variation" team studies the role of transcriptional and post-transcriptional epigenetic modifications in the adaptability of plants to environmental stresses. The group is also interested in natural epigenetic variability related to stress responses.

- "Epigenetics" team is investigating the interactions among several RNA Quality Control pathways and RNA silencing, as well as the integration of these pathways during the control of endogenous or exogenous aberrant RNAs (deriving from viruses and transgenes, for example). The group also is interested in small RNA-induced changes in epigenetic chromatin states, the stability of these states and their role in natural variability.

- "Chromatin Dynamics" team studies LHP1 chromatin complexes as well as the mechanisms by which these complexes regulate gene expression. The group also is interested in nuclear architecture and the relationships between structure / function of the genome at the transition between differentiated and dedifferentiated states.

 

 

 
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