The department “Dynamics and Expression of the Genome”
employs genetics, cytology, molecular biology and protein biochemistry
to investigate the essential mechanisms controlling the structure
and function of the genome during meiosis (recombination) and genomic
shock (polyploidism), and following biotic and abiotic stresses
(control of transposable elements and variations in the epigenetic
state of genes implicated in stress responses). Our department also
studies the transcriptional (chromatin dynamics and the stability
of epigenetic states) and posttranscriptional (processing of endogenous
and exogenous aberrant RNAs by RNA Quality Control and RNA silencing
pathways) mechanisms controlling gene expression. These studies
are carried out in several model plants including the crucifers
Arabidopsis thaliana and Brassica napus, the solanaceous
species Nicotiana tabacum and Solanum esculentum
and basal land plants such as the moss Physcomitrella patens.
(MeioRec) team studies the key steps
of meiosis and meiotic recombination (meiotic cell cycle regulation,
initiation of meiotic recombination, double strand break repair
pathways, control of the crossing over/non crossover ratio, polyploidization
mechanisms, control of recombination in polyploids, and the role
of chromatin structure on the distribution of meiotic recombination
events). A subset of our group also studies somatic homologous recombination
with the aim of developing gene targeting strategies.
team examines the impact of retrotransposons in Solanaceae,
from the control of their activities (particularly in response to
stress or allopolyploidization) to their molecular evolution, as
well as their evolutionary and functional impact. The group also
looks at the impact of transcriptional activation of retrotransposons
on the expression of cellular genes.
variation" (VARepi) team
studies the role of transcriptional and post-transcriptional
epigenetic modifications in the adaptability of plants to environmental
stresses. The group is also interested in natural epigenetic variability
related to stress responses.
(epiARN) team is investigating the interactions among
several RNA Quality Control pathways and RNA silencing, as well
as the integration of these pathways during the control of endogenous
or exogenous aberrant RNAs (deriving from viruses and transgenes,
for example). The group also is interested in small RNA-induced
changes in epigenetic chromatin states, the stability of these states
and their role in natural variability.
team CHRODYNO, "Chromatin
Dynamics" (CHROMA) former team studied LHP1 chromatin
complexes as well as the mechanisms by which these complexes regulate
gene expression. The group also is interested in nuclear architecture
and the relationships between structure / function of the genome
at the transition between differentiated and dedifferentiated states.